The effect of statin administration on IL-6 and IL-1b expression in peripheral blood mononuclear cells of a hypertensive patient with SARS-CoV-2 spike protein stimulation
Aim The infection of the SARS-CoV-2 virus potentially causes a cytokine storm with elevated IL-6 and IL-1β levels. Statin therapy was common among COVID-19 patients due to their cardiovascular comorbidities. However, the effect of statins on COVID-19 infection is unclear. The aim of this study was to evaluate the impact of statin administratio...
By Andrianto Andrianto, Budi Susetyo Pikir, Rizki Amalia, Teuku Yusriza, Fatimah Alzahra, Maya Qurota A’yun, Michael Jonatan
Adherence to preventive behaviours and risk of COVID-19 infection: a case-control study
Aim To investigate the relationship between adherence to preventive behaviors and risk of COVID-19 infection.Methods In this case-control study, 491 participants were selected through convenience sampling. First, the samples of the casegroup (COVID-19 patients) were selected, and then the control group was matched with the case group based on age, ...
By Reza Hosseinabadi, Shoorangiz Biranvand, Khatereh Anbari
Regulation of p53 and survivin by Curcuma longa extract to caspase-3 dependent apoptosis in triple negative breast cancer cells
Aim Triple negative breast cancer cells (TNBC) are the population of breast cancer cells that are responsible for cancer recurrence and apoptosis resistance. Unfortunately, current therapies have limited efficacy to TNBC population due to apoptosis resistance and chemoresistance. Tumour suppressor p53 and survivin are primary targets for TNBC thera...
By Deryne Anggia Paramita, Dedy Hermansyah, Desiree Anggia Paramita, Nur Dina Amalina
Vascular comorbidities in patients with multiple sclerosis and their impact on physical disability
Aim Given the impact of vascular comorbidities (VC) on the diagnosis, treatment, and outcome of multiple sclerosis (MS), weexamined the incidence and correlation of VC and risk factors for vascular disease in people with MS (PwMS) compared to the general population, and the impact on the physical disability of patients.Methods Cross-sectional study...
By Daliborka Tadić, Sanja Grgić, Aleksandra Dominović-Kovačević, Majda Nazalević-Bursać, Srđan Mavija, Vlado Đajić
High results and lower cost in four-bone arthrodesis with retrograde screws
Aim To describe the technique of the four-corner fusion with two retrograde crossed headless screws in cases of carpal collapse.Methods This technique is a consolidated procedure performed in cases of scaphoid non- union advanced collapse (SNAC) typeII and III, scapholunate advanced collapse (SLAC) type II and III and in other cases of carpal colla...
By Dariush Ghargozloo, Alessandro Tomarchio, Mauro Ballerini, Emanuela Saccalani, Giorgio Grazioli, Gianpaolo Chitoni
Sporadic chromosome translocation frequencies in lymphocyte cultures – a retrospective study in a cohort of patients from Bosnia and Herzegovina
Aim Chromosome translocations are considered as one of the most severe forms of genome defects. Because of the clinical significance of chromosome translocations and scarce data on the incidence of sporadic translocations in population of Bosnia and Herzegovina, we aimed to report sporadic translocation frequencies in samples karyotyped in our labo...
By Sanin Haverić, Anja Haverić, Maida Hadžić, Tamara Ćetković, Lejla Čaluk Klačar, Rifat Hadžiselimović
TGF-1 biomarker level evaluation on fracture healing in a murine model with a bone defect after stromal vascular fraction application
Aim Bone defect is a challenge even for experienced orthopaedic surgeons and it is a significant cause of morbidity in patients and a source of high economic burden in health care. A severe bone defect is a condition whereby the bone tissue cannot undergo natural healing despite surgical stabilization and requires further surgical intervention. Str...
By Panji Sananta, Respati S Dradjat, Rizqi Daniar Rosandi, Lasa Dhakka Siahaan
Psychosocial influence of COVID-19 on healthcare workers
Aim To assess a psychosocial impact of the Coronavirus disease 2019 (COVID-19) on health care workers and to quantify the size of depression symptoms, anxiety and stress levels.Methods This cross-sectional study used an anonymous online survey questionnaire as a research instrument and it included 114health workers of all profiles from the Sarajevo...
By Aleksandra Pašić, Slavenka Štraus, Emina Smajić, Ermin Begović, Ilirijana Haxhibeqiri-Karabdić, Nada Spasojević
Clinical efficacy of diazepam after whiplash: a randomized controlled study
Aim To investigate the role of short-term diazepam therapy for improving long-term outcomes and reducing neck pain after whiplash injury.Methods A total of 89 patients suffering from whiplash injury were included. They were randomly assigned into 2 groups: groupA (study group), and group B (control group). The test group was prescribed with diazepa...
By Edin Mešanović, Ćamil Habul, Ermin Hadžić
Pregnancy outcomes of COVID-19 positive pregnant women at the Cantonal Hospital Zenica, Bosnia and Herzegovina
Aim To investigate clinical presentation of COVID-19 infection in pregnancy, its course during pregnancy, effects on pregnancyoutcomes for both mothers and newborns as well as the potential for vertical transmission.Methods This retrospective observational study included all identifi ed COVID-19-positive pregnant women admitted to the Cantonal Hosp...
By Jasmin Hodžić, Bedrana Muračević, Hana Štimjanin, Rasim Iriškić, Muamera Husika