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Vol 22, No 2, (August 2025)

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Authors in this issue:

Abdul Hammeed Hameed, Abeer Abdel Rasool, Aditya Sri Listyoko, Admir Abdić, Admir Keserovic, Adna Ašić, Adnan Musanović, Agung Putra, , Ahmedz Widiasta, Aida Đozo, Aigerim Imanbayeva, Aigul Zhumasheva, Ajay Kumar, Alberto Casto, Aldy Safruddin Rambe, Alisa Krdzalic, Amar Skakić, Amel Krkalić, Amela Begić, Amela Pašić, Amil Topuz, Amila Huremović, Amina Saračević, Amir Bećirović, Amra Adrovic, Anara Tulyayeva, Anes Jogunčić, Anis Cerovac, Antonio Mascio, Arina Brkić, Arini Dewi Antari, Arip Koyshybaev, Asmir Aldžić, Aytan Aliyeva, Azamat Zharylgapov, Azra Durak-Nalbantić, Azra Lukavačkić, Beibit Baizakov, Bhaskar Sarkar, Camillo Fulchignoni, Carlo Perisano, Chiara Comisi, Cindy Carrissa Primaputri, Damiano Longo, Damir Ramić, Danijel Gajić, Dany Hilmanto, Debabrata Sircar, Dedi Rachmadi, Dedy Hermansyah, Dijana Hasić, Dinara Zholmukhamedova, Dino Pećar, Duaa AL Maghaireh, Dubravko Habek, Dunja Aksentijevic, Džana Kavazović, Edina Đozić, Edina Lazović Salčin, Effi Rohani Nuzul Sari, Elisa Troiano, Elisabetta Pataia, elma catovic-baralija, Emina Bajrić Čusto, Emina Kiseljaković, Emina Mameledžija, Emina Vukas - Salihbegović, Emir Bećirović, Emir Tupković, Endi Taris Pasaribu, Fadhli Rizal Makarim, Faris Suljagić, Fasihah Irfani Fitri, Fatih Aslak, Fithria Aldy, Francesco Farine, Fuad Pašić, Fuad Zukić, Ghaitsa Hasnadia Anggoro, Giorgio Giannini, Giulio Maccauro, Giuseppe Rollo, Goran Krdžalić, Harun Avdagić, Harun Mandra, Harun Selimović, Hayat S. Abu Shaikha, Iffan Alif, Igor Rausa, Iin Noor Chozin, Irshad Ahmad, Ivana Čeko, Ivana Iveljic, Jacopo Conteduca, Jafar A. Alshraideh , Kania Haura Chalisaturahmi, Karina Sugih Arto, Kenan Barut, Kenana Ljuca, Lamija Mlaćo, Lana Salihefendić, Lejla Alidzanovic Nurkanovic, Liqaa Alkhalidy, Luigi Meccariello, Madhur Uniyal, Mariam Kawafha, Marzhan Aitmagambetova, Md Qamar Azam, Mehmet Yildiz, Mehvish Mukhtar, Meidona Nurul Mila, Minela Bećirović, Mirsad Babić, Mirsad Dorić, Mirza Babić, Mirza Izmirlija, Muhammad Al Anas, Mutiara Baitina, Nadina Ljuca, Naida Mulahuseinović, Namira Latifah Sa'adah, Nauryzbay Imanbayev, Nejira Handžić, Nicola Mondanelli, Nijaz Tihić, Nilesh Jagne, Nina Čamdžić, Nurgul Kereyeva, Omar Suljagić, Oya Koker, Ozgur Kasapcopur, Pimpin Utama Pohan, Radivoj Jadrić, Ragib Pugonja, Rahmad Rahmad, Raka Dutra Pratama, Rania Maharani, Ratko Knežević, Rijad Konjhodžić, Rini Rossanti, Sabaheta Hasić, Sabina Cemalovic, Sabina Prevljak, Sabina Šegalo, Sajra Uzicanin, Samir Bajrić, Šejla Cerić, Selma Jusufović , selma Agić-Bilalagić, Selma Durgut, Selma Hasić, Senada Selmanović, Sezgin Sahin, Suada Kuskunović-Vlahovljak, Sugeng Ibrahim, Suha Abed, Tarik Odobašić, Taufik Ashar, Timur Cerić, Titiek Sumarawati, Tommaso Greco, Vedad Herenda, Vito Mahendra Eka Saputra, Windy Listiana, Yani Jane R. Sugiri, Yaser Mohammedali, Yerbolat Iztleuov, Yunita Eka Wati, Zarina Babić Jušić, Zhanna Satenova, Zinka Huseinbegovic,

Published: 25.08.2025.

Contents

25.08.2025. Original article New and Emerging Medical Entities
Assessment of Recipient Characteristics and Blood Product Usage Patterns at the Transfusion Medicine Institute of FBiH in 2023.

ABSTRACT Aim: This study aimed to assess recipient characteristics and blood product usage patterns at the Transfusion Medicine Institute of Federation of Bosnia and Herzegovina(FB&H) in 2023, focusing on clinic-specific blood requests. Methods: The study was conducted from 1st January to 29th December 2023. Data were collected from the Renov...

By ELMA CATOVIC-BARALIJA

25.08.2025. Original article Translational and Clinical Research
The Relationship between Neutrophil-Lymphocyte Ratio and Ocular Manifestations in Children with Human Immunodeficiency Virus

ABSTRACT Context: Children with Human Immunodeficiency Virus (HIV) face elevated risks of systemic and ocular complications, potentially leading to blindness, particularly in developing countries where cases are rising.  Aim To investigate the association between neutrophil-lymphocyte ratio (NLR) and ocular manifestations in children with Hu...

By FITHRIA ALDY

25.08.2025. Original article Translational and Clinical Research
Clinicopathological Characteristics of Young-Onset Breast Cancer Patients Stratified by Molecular Subtypes at H. Adam Malik Hospital

Aim To examine and evaluate the clinicopathological characteristics of young-onset breast cancer across molecular subtypes in patients from Southeast Asia, with a specific focus on those treated at H. Adam Malik Hospital, Indonesia. Methods A descriptive observational study with a cross-sectional design was conducted on medical records of breast c...

By RAKA DUTRA PRATAMA, DEDY HERMANSYAH, PIMPIN UTAMA POHAN

25.08.2025. Original article
Quality of life among adults with hearing loss in Cantonal Hospital of Zenica: A cross-sectional study

Aim To assess Qualitiy of life (QoL) in adults by comparing two groups, the one with diagnosed hearing loss (HL) and the other without hearing complaints. Methods This cross-sectional study included 110 consecutive voluntary adult  patients divided in two groups: patients with hearing loss and control group. All participants , after examinati...

By AMEL KRKALIĆ, ADMIR KESEROVIC, HARUN SELIMOVIĆ, HARUN MANDRA, ANES JOGUNČIĆ, RAGIB PUGONJA

25.08.2025. Review paper Translational and Clinical Research
The Caesarean section epidemic: a call for a reduction in the number of Caesarean sections

A caesarean section (CS) is an obstetric surgical intervention and mode of delivery which aims to finish the pregnancy surgically. CS are one of the most important surgical interventions in modern obstetrics and have lead to a significant reduction of fetal and maternal mortality. However, it is important to take into consideration that CS can have...

By ANIS CEROVAC, DAMIR RAMIĆ, DUBRAVKO HABEK, ASMIR ALDŽIĆ, RATKO KNEŽEVIĆ

25.08.2025. Original article Translational and Clinical Research
Effectiveness of Hemodialysis with hemoperfusion as a therapeutic modality in pediatric chronic kidney disease

Introduction Children receiving regular kidney replacement therapy frequently encounter a state of heightened inflammation, which is evident through symptoms like loss of appetite and elevated levels of β-2 microglobulin (B2M) in their bloodstream. This loss of appetite leads to a reduction in muscle mass, which, on a biochemical level, can r...

By AHMEDZ WIDIASTA, RINI ROSSANTI, DEDI RACHMADI, DANY HILMANTO

25.08.2025. Original article Translational and Clinical Research
Analysis of Interleukin 8 (IL-8) Levels, Blood Urea Nitrogen/Albumin Ratio, Pneumonia Severity Index, and Length of Stay in Patients Undergoing Pulmonary Rehabilitation and Shortwave Diathermy

Objective: This study aims to analyze the effects of Pulmonary Rehabilitation (PR) and short-wave Diathermy (SWD) on the Blood Urea Nitrogen (BUN)/Albumin ratio, Pneumonia Severity Index (PSI), IL-8 levels, and length of stay (LOS) in hospitalized pneumonia patients. Material and method: This is a randomized experimental study with a pre-post cont...

By CINDY CARRISSA PRIMAPUTRI, YANI JANE R. SUGIRI, IIN NOOR CHOZIN, ADITYA SRI LISTYOKO, YUNITA EKA WATI, RAHMAD RAHMAD

25.08.2025. Original article Biochemistry
Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study

ABSTRACT AimAcute respiratory infections caused by viral pathogens are the most common reason for hospitalization of children. Annually, 150 million infants worldwide are diagnosed with bronchiolitis, and 2-3% of them are hospitalized. This study aimed to compare bronchiolitis severity before and after the COVID-19 pandemic. MethodsThis retrospec...

By AMINA SARAČEVIĆ, AMELA PAŠIĆ, NIJAZ TIHIĆ, AZRA LUKAVAČKIĆ, AMILA HUREMOVIĆ, DŽANA KAVAZOVIĆ

25.08.2025. Original article Biochemistry
Clinical and Nutritional Assessment of Iron Deficiency Anemia in Children Under Two Years of Age

Aim To determine the frequency of iron deficiency anemia IDA, its causes, feeding behaviors, and preventive measures among children under the age of two. Methods This cross-sectional study included 110 children  presenting with IDA and compared them with 100 children  with normochromic normocytic anemia as the comparison group. Results ...

By ABEER ABDEL RASOOL, ABDUL HAMMEED HAMEED, LIQAA ALKHALIDY

25.08.2025. Original article Translational and Clinical Research
Prevalence of Metabolic Syndrome in Young Adults: A Risk Factor for Future Cardiovascular Disease

Aim To investigate the correlation between metabolic syndrome, especially waist circumference, and cardiovascular risk in young adults. Methods In this retrospective cohort study,137 patients under 50 years who visited the Family Medicine Service of Tuzla Health Center were included. Data were collected from patient records and through physical ex...

By SABINA CEMALOVIC, EMINA BAJRIĆ ČUSTO, SENADA SELMANOVIĆ, SAMIR BAJRIĆ, DIJANA HASIĆ, DANIJEL GAJIĆ

25.08.2025. Original article Microbiology
Correlation between Biofilm Development and Antibiotic Resistance in Staphylococcus haemolyticus

Aim: This study aimed to evaluate antibiotic resistance, biofilm formation, and the presence of virulence-associated genes in Staphylococcus haemolyticus isolates. Methods: Clinical specimens were obtained from patients in Mosul city. Antibiotic susceptibility was determined using the Kirby–Bauer disk diffusion method against fourteen antibi...

By YASER MOHAMMEDALI, SUHA ABED

25.08.2025. Original article Translational and Clinical Research
Acquired demyelinating diseases of the central nervous system in children: A single center experience

Background: Acquired demyelinating diseases (ADD) of central nervous system encompasses a wide spectrum of neurological symptoms depending on the location and the severity of demyelination. The aim of this study is to present the frequency and the clinical, immunological, and radiological characteristics of ADD in pediatric patients at the Pediatri...

By EMINA VUKAS - SALIHBEGOVIĆ, SAJRA UZICANIN, ZINKA HUSEINBEGOVIC

25.08.2025. Original article Pathology
Prevalence of cervical cytology abnormalities and its correlation with HPV infection among different age groups: Single institution five-year experience

Aim to investigate the prevalence of cervical cytology abnormalities over five years and to correlate it with patient’s age and presence/absence of HPV infection. Methods Pap findings of 614 women with documented cervical abnormalities and Pap findings of HPV-positive women (regardless of whether the Pap test showed an intraepithelial abnorm...

By NINA ČAMDŽIĆ, ARINA BRKIĆ, EMINA MAMELEDŽIJA, MIRSAD BABIĆ, MIRSAD DORIĆ, SUADA KUSKUNOVIĆ-VLAHOVLJAK, EDINA LAZOVIĆ SALČIN

25.08.2025. Original article Biochemistry
Association of triglyceride glucose index as insulin resistance measure and waist to hip ratio in apparently healthy students of University of Sarajevo

Aim. This study aimed to reveal the prevalence of the insulin resistance (IR) identified by triglyceride glucose index (TyG index) among students of University of Sarajevo. The impact of visceral fat level and waist to hip ratio measures on TyG value in students has been investigated. Patients and methods. Study included 160 apparently healthy stud...

By SABAHETA HASIĆ, AIDA ĐOZO, EMINA KISELJAKOVIĆ, RADIVOJ JADRIĆ, LAMIJA MLAĆO, AMIL TOPUZ, SELMA HASIĆ

25.08.2025. Original article
Risk factors for developing respiratory complications after coronary artery bypass surgery

Aim: This study aims to identify independent risk factors associated with postoperative respiratory complications (PRC) in patients undergoing coronary artery bypass surgery (CABG). Methods: A retrospective cohort study was conducted on 98 patients (82 male, 16 female) who underwent CABG at the Cardiovascular Surgery Clinic, University Hospital Tu...

By ALISA KRDZALIC, AMAR SKAKIĆ, HARUN AVDAGIĆ, FUAD PAŠIĆ, TARIK ODOBAŠIĆ, GORAN KRDŽALIĆ

25.08.2025. Original article Translational and Clinical Research
Impact of Tourniquet Type on Outcomes in ORIF of Pediatric Distal Radius Fractures

Purpose:  The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis was that the clinical results could be increased after use of the silicone ring tourniquet. Methods: The st...

By JACOPO CONTEDUCA, DAMIANO LONGO, ALBERTO CASTO, GIORGIO GIANNINI, LUIGI MECCARIELLO, IGOR RAUSA, GIUSEPPE ROLLO

25.08.2025. Original article
Effect of MSCs on vascular endothelial growth factor (VEGF), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triglyceride, pancreatic beta cells and insulin resistance in Oobese Type 2 diabetic rat model Effect of MSCs on Vascular Endothelial Growth Factor (VEGF), C-Reactive Protein (CRP), Tumor Necrosis Factor-Alpha(TNF-α), Triglyceride, Pancreatic Beta Cells And Insulin Resistance in Obese Type 2 Diabetic Rat Model

Aim to investigate the potential of SG followed by injection of MSCs in type 2 diabetic rats with obesity in improving IR. Methods This study used a pre and post-control group design with 24 rats divided into three groups: Control (C), SG, and SG + MSCs (SG+M). On day 10, the level of vascular endothelial growth factor (VEGF), tumor necrosis facto...

By VITO MAHENDRA EKA SAPUTRA, AGUNG PUTRA,, TITIEK SUMARAWATI, SUGENG IBRAHIM, MEIDONA NURUL MILA, ARINI DEWI ANTARI, FADHLI RIZAL MAKARIM, IFFAN ALIF, GHAITSA HASNADIA ANGGORO, NAMIRA LATIFAH SA'ADAH, RANIA MAHARANI, WINDY LISTIANA

25.08.2025. Original article
A rare case of high-grade synovial sarcoma of the hindfoot

Aim: To report our personal experience in hindfoot reconstruction using an anterolateral thigh (ALT) free flap following radical resection of a high-grade synovial sarcoma. Methods The patient underwent clinical and imaging assessments, and a biopsy of the lesion confirmed the diagnosis of synovial sarcoma (SS) of the hindfoot. A multidisciplinary...

By CHIARA COMISI, CAMILLO FULCHIGNONI, ANTONIO MASCIO, FRANCESCO FARINE, ELISA TROIANO, NICOLA MONDANELLI, ELISABETTA PATAIA, GIULIO MACCAURO, CARLO PERISANO, TOMMASO GRECO

25.08.2025. Original article Translational and Clinical Research
Comparison of coronary artery calcium scores between patients with and without type 2 diabetes

ABSTRACT Aim This study compared the extent of coronary artery calcification in patients with and without type 2 diabetes mellitus (T2DM) using Coronary Computed Tomography Angiography (CCTA). Methods This retrospective, observational cohort study included 107 patients who underwent CCTA at the Clinical Centre of the University of Sarajevo betwee...

By MIRZA BABIĆ, ZARINA BABIĆ JUŠIĆ, SABINA PREVLJAK, FUAD ZUKIĆ, MINELA BEĆIROVIĆ, AMIR BEĆIROVIĆ, ADMIR ABDIĆ, EMIR BEĆIROVIĆ

25.08.2025. Original article Translational and Clinical Research
Association of Botulinum toxin treatment due to aesthetic corrections in the face with the level of happiness, anxiety and depression

Aim Any aesthetic procedure in the head and/or in the face might have an impact on psychological status of the treated participants. Aim of this study was to investigate whether Botulinum toxin treatment for aesthetic purpose in the face influences on the level of happiness, depression and anxiety. Methods This prospective cohort observational stu...

By OMAR SULJAGIĆ, EMIR TUPKOVIĆ, KENANA LJUCA, FARIS SULJAGIĆ, NADINA LJUCA

25.08.2025. Original article Pathology
Correlation of Ki67 expression with estrogen receptor (ER) and progesterone receptor (PR) status in breast cancer

Aim To determine whether Ki67 can be predicted through its correlation with the estrogen receptor (ER) and progesterone receptor (PR), to identify breast cancer subtypes and evaluate cell proliferation level and prognosis. Methods Patient clinical data were collected from medical records and pathology laboratory reports at Teaching Hospital, Facul...

By DEDY HERMANSYAH, MUHAMMAD AL ANAS, KANIA HAURA CHALISATURAHMI, MUTIARA BAITINA, KARINA SUGIH ARTO, ENDI TARIS PASARIBU

25.08.2025. Original article Translational and Clinical Research
Correlation Between Brain-Derived Neurotrophic Factor and Cognitive Function in Older Adults

Aim Brain Derived Neurotrophic Factor (BDNF) plays a crucial role in supporting neuronal survival, promoting neurogenesis, and enhancing synaptic plasticity, all of which are vital for cognitive health. Aim of this study was to investigate the relationship between BDNF levels and cognitive impairment in the elderly population. Methods This was a c...

By EFFI ROHANI NUZUL SARI, FASIHAH IRFANI FITRI, ALDY SAFRUDDIN RAMBE, TAUFIK ASHAR

25.08.2025. Original article Translational and Clinical Research
The long-term follow up of patients with oligoarticular juvenile idiopathic arthritis: a single center experience.

AimTo evaluate the clinical course and outcomes of oligoarticular juvenile idiopathic arthritis(JIA) patients from 2003 to 2021, identifying factors linked to severe disease and complications. Methods We analyzed 208 oligoarticular JIA patients followed at Cerrahpaşa Medical School, using medical records. Continuous variables were compa...

By AYTAN ALIYEVA, AMRA ADROVIC, FATIH ASLAK, OYA KOKER, MEHMET YILDIZ, SEZGIN SAHIN, KENAN BARUT, OZGUR KASAPCOPUR

25.08.2025. Original article Translational and Clinical Research
Impact of a Modified Discharge Program on Health Outcomes After Coronary Bypass Surgery: A Randomized Trial

Aim:  This study examines the effects of implementing a modified Re-Engineered Discharge (RED) intervention on Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and readmission rates 30 days after Coronary Artery Bypass Graft (CABG) surgery. Methods A randomized clinical trial was conducted with 104 participants who underwent...

By HAYAT S. ABU SHAIKHA, DUAA AL MAGHAIREH, MARIAM KAWAFHA, JAFAR A. ALSHRAIDEH

25.08.2025. Original article Translational and Clinical Research
Prognostic significance of CD163 expression in colorectal cancer stroma: a retrospective cohort study

Aim. Colorectal cancer (CRC) ranks among the leading causes of cancer-related mortality worldwide, with significant incidence and mortality rates recorded in Kazakhstan. CRC poses a substantial healthcare burden, prompting investigations into novel prognostic markers. Aim. This study investigates the prognostic significance of CD163 expression in ...

By NAURYZBAY IMANBAYEV, YERBOLAT IZTLEUOV, ARIP KOYSHYBAEV, AIGUL ZHUMASHEVA, BEIBIT BAIZAKOV, NURGUL KEREYEVA, ZHANNA SATENOVA, AIGERIM IMANBAYEVA, ANARA TULYAYEVA, DINARA ZHOLMUKHAMEDOVA, MARZHAN AITMAGAMBETOVA, AZAMAT ZHARYLGAPOV

25.08.2025. Original article Molecular Biology
OPTIMIZATION OF ILLUMINA® NEXTERA™ XT LIBRARY PREPARATION FOR THE MITOCHONDRIAL GENOME SEQUENCING AND CONFIRMATORY SANGER SEQUENCING

Aim: Due to increasing use of mitochondrial DNA (mtDNA) sequencing in both forensic practice and clinical disease research, this study explores the optimization of the next-generation sequencing (NGS) method for whole mitochondrial genome analysis on the Illumina MiSeq platform. Methods: Initial attempts using pre-made commercial primers were unsuc...

By NEJIRA HANDŽIĆ, DINO PEĆAR, SELMA DURGUT, NAIDA MULAHUSEINOVIĆ, IVANA ČEKO, ADNA AŠIĆ, MIRZA IZMIRLIJA, SABINA ŠEGALO, LANA SALIHEFENDIĆ, RIJAD KONJHODŽIĆ

25.08.2025. Original article Translational and Clinical Research
Role of postoperative serum thyroglobulin as a prognostic factor for the outcome of radioactive iodine therapy of follicular thyroid cancer.

Aim To investigate the relationship between postoperative serum thyroglobulin level ​​and outcome of therapy with I-131 of follicular thyroid cancer. Methods A total of 106 patients with follicular thyroid cancer who were being treated and monitored at the Clinic for Nuclear Medicine at Clinical Center of the University of Sarajevo were included. ...

By SELMA AGIĆ-BILALAGIĆ, ŠEJLA CERIĆ, AMELA BEGIĆ, AZRA DURAK-NALBANTIĆ, EDINA ĐOZIĆ, TIMUR CERIĆ

25.08.2025. Original article Translational and Clinical Research
Fluoropyrimidine adjuvant chemotherapy leads to long-term impact on coronary arteries, blood cell profile and iron in colorectal cancer survivors

Aim To assess whether colorectal carcinoma (CRC) survivors 5 years post-fluoropyrimidine (5-fluorouracil and capecitabine) chemotherapy (ChemT) have increased presence of subclinical coronary artery disease (CAD), lower iron and altered blood cell composition. Methods This prospective, 2 year, single-center study used invasive coronary angiography...

By IVANA IVELJIC, LEJLA ALIDZANOVIC NURKANOVIC, ALISA KRDZALIC, DUNJA AKSENTIJEVIC

25.08.2025. Systematic review Pharmacology
Fixed-dose combination antihypertensives in patients with chronic kidney disease: A systematic literature review

Aim To systematically review the efficacy and safety of fixed-dose combination (FDC) antihypertensive agents in chronic kidney disease (CKD). Methods This systematic review included studies from January 2014 to December 2023 that evaluated FDC antihypertensives in CKD. We searched The PubMed, Embase, and the Cochrane Library databases were searche...

By VEDAD HERENDA, SELMA JUSUFOVIĆ, ADNAN MUSANOVIĆ

25.08.2025. Original article Translational and Clinical Research
Untargeted Urinary Metabolomic Profile of Isolated Chest Trauma Patients.

Untargeted Urinary Metabolomic Profile of Isolated Chest Trauma Patients. ABSTRACT: Aim To explore the untargeted urinary metabolomic biomarkers in isolated chest injury patients. Methods It was a prospective study for 1 year period including the patients of isolated chest trauma as per inclusion criteria. Day 0, 3, and 7 urine samples from pat...

By IRSHAD AHMAD, DEBABRATA SIRCAR, MADHUR UNIYAL, MEHVISH MUKHTAR, AJAY KUMAR, BHASKAR SARKAR, NILESH JAGNE, MD QAMAR AZAM

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