This is an early access version
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Cantonal hospital "Dr Irfan Ljubijankić" , Bihać , Bosnia and Herzegovina
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Cantonal hospital "Dr Irfan Ljubijankić" , Bihać , Bosnia and Herzegovina
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Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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University Clinical Center Tuzla , Tuzla , Bosnia and Herzegovina
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University Clinical Center Tuzla , Tuzla , Bosnia and Herzegovina
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Cantonal hospital "Dr Irfan Ljubijankić" , Bihać , Bosnia and Herzegovina
University Clinical Center Tuzla , Tuzla , Bosnia and Herzegovina
ABSTRACT
Aim This study compared the extent of coronary artery calcification in patients with and without type 2 diabetes mellitus (T2DM) using Coronary Computed Tomography Angiography (CCTA).
Methods This retrospective, observational cohort study included 107 patients who underwent CCTA at the Clinical Centre of the University of Sarajevo between July and December 2024. Patients were divided into two groups: those with T2DM (n=51) and those without T2DM (n=56). Laboratory parameters, demographic data, and calcium scores were analysed. The calcium score was categorised into six groups based on cardiovascular risk and the comparison was made using appropriate statistical analysis.
Results Patients with T2DM had significantly higher calcium scores than non-diabetic patients (p=0.0001). In the T2DM group, 35.3% of patients had a calcium score >400, indicating high cardiovascular risk. Patients without diabetes were more frequently classified into lower-risk categories (p=0.0001). A significant correlation was found between calcium score and age (r=0.442, p=0.001) and gender (r=-0.218, p=0.024), with men having higher calcium scores. Additionally, total cholesterol, LDL, and uric acid levels were significantly higher in diabetic patients (p=0.005; p=0.025; p=0.03, respectively).
Conclusion This study confirms a strong association between T2DM and increased coronary artery calcification. Age and male gender are significant predictors of higher calcium scores. Further research is needed to explore these relationships, particularly within the Bosnian population.
Keywords Coronary angiography, coronary artery calcification, coronary disease, diabetes mellitus type 2
Conceptualization, M.B. and Z.B.J.; Data curation, M.B. and Z.B.J.; Formal Analysis, M.B. and Z.B.J.; Investigation, M.B., Z.B.J., S.P., F.Z., A.A. and E.B.; Methodology, M.B., Z.B.J. and E.B.; Project administration, M.B. and Z.B.J.; Software, M.B. and M.B.; Visualization, M.B. and A.A.; Writing – original draft, M.B. and Z.B.J.; Resources, Z.B.J. and A.B.; Supervision, S.P. and F.Z.; Validation, S.P., M.B. and E.B.; Writing – review & editing, S.P., F.Z., M.B., A.B. and E.B. All authors have read and agreed to the published version of the manuscript.
No specific funding was received for this study.
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