This is an early access version
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Clinical Biochemistry and Laboratory Medicine, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Department for Laboratory Technologies, Faculty of Health Sciences, University of Sarajevo, Sarajevo, Bosnia and Herzegovina, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Clinic for Infectious Diseases, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Clinic for Infectious Diseases, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Clinical Biochemistry and Laboratory Medicine, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Clinical Biochemistry and Laboratory Medicine, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Unit fo Clinical Microbiology, Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina
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Department for Pathohistology and Cytology, ASA Hospital , Sarajevo , Bosnia and Herzegovina
Institute for Transfusion Medicine, Federation of Bosnia and Herzegovina , Sarajevo , Bosnia and Herzegovina
Aim To describe the clinical picture and laboratory findings, as well as to examine the significance of novel hemogram-derived inflammatory indices in adult patients with measles admitted to a tertiary hospital.
Methods This prospective, descriptive, and analytical study included adult patients over 18 years of age with clinical signs of measles, admitted at the Clinic for Infectious Diseases, Clinical Center of Sarajevo. Upon admission, medical history, physical examination, and laboratory analyses were conducted from February 2024 to 31 December 2024.
Results The study included 124 patients, 52 men and 72 were women with a mean age of 38.33±13.18 years. The most common symptoms in most patients were rash (95.97%) and cough (69.36%). Neutrophilia (63.7%) and lymphopenia (74.19%) were the main hematological features along with elevated C-reactive protein (CRP) (95.17%) and transaminase (75%) in the vast majority of patients. The results of laboratory analyzes also indicated hyponatremia and hypokalemia, with elevated values of the enzymes creatine kinase (CK) and lactate dehydrogenase (LDH). The CRP, as the most commonly elevated laboratory parameter, showed positive, significant correlation with Neutrophil/Lymphocyte ratio (NLR), Systemic Inflammation Response Index (SIRI) (p<0.05) and Systemic immune-inflammation index (SII) and Aggregate Index of Systemic Inflammation (AISI) (p<0.01).
Conclusion Adult measles was associated with significant inflammation, hematologic changes, and organ involvement, with CRP showing strong correlations with hemogram-derived indices. These findings suggesting that they may be useful in diagnostics of measles.
Conceptualization, B.H., A.M., S.H., E.H.H., L.A., E.Š. and A.S.; Data curation, B.H., A.M., S.H., E.H.H., L.A. and A.M.; Formal Analysis, B.H., A.M., S.H., E.H.H., L.A., E.Š. and A.S.; Investigation, B.H., A.M., S.H., E.H.H., L.A., A.M., E.Š. and A.S.; Methodology, B.H., A.M., S.H., E.H.H., L.A., A.M., E.Š. and A.S.; Project administration, B.H., A.M., S.H., E.H.H., L.A., A.M., E.Š. and A.S.; Resources, B.H., A.M., S.H., E.H.H., L.A. and A.S.; Software, B.H., E.Š. and A.S.; Supervision, B.H., E.H.H. and L.A.; Validation, B.H., A.M., S.H., E.H.H., L.A., E.Š. and A.S.; Visualization, B.H. and E.Š.; Writing – original draft, B.H., E.H.H., L.A., E.Š. and A.S.; Writing – review & editing, B.H., E.H.H., L.A. and E.Š. All authors have read and agreed to the published version of the manuscript.
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