Aim: To synthesize applications of Artificial Intelligence (AI) and big data in chronic disease management, evaluate clinical and economic outcomes, challenges, and future directions. Methods: A comprehensive search was conducted across PubMed, Scopus, Web of Science, IEEE Xplore, and CINAHL for studies published between 2015-2025, following the P...

By SANA'A ABU-QBEITAH, MUAYYAD AHMAD

Aim: To identify the donor and procedural parameters that influence the platelet yield obtained by apheresis. Methods: A retrospective observation study of 60 plateletpheresis in the Blood Transfusion Institute of Federation of Bosnia and Herzegovina in Sarajevo, was done. Plateletpheresis were performed using Amicus cell separator with platelet c...

By GORANA AHMETOVIC-KARIC, KENAN MEHIC, SELIM ARIFOVIC, AJSA ZILDZIC, FARUK BRADARIC

ABSTRACT Aim Alloimmunization depends on the type of the erythrocyte antigen, as well as the number of transfused doses of blood and recipient factors reflected in genetic and immunological status, comorbidities and therapy. The aim was to determine the frequency and type of antierythrocyte antibodies, to examine the correlation between the number...

By SVETLANA JOVIĆ LACKOVIĆ, ALMIRA ĆOSIĆKIĆ

Aim To evaluate 3 point-of-care testing (POCT) devices in testing HbA1c: the Simplex TASTM101 (Tascom Co. Ltd., South Korea), which utilizes an enzymatic method, and two immunoassay-based devices, the Zybio Q8 Pro and Zybio EXR 110 (Zybio Inc., China). Methods A total of 40 whole blood samples with EDTA anticoagulant were collected patients underg...

By WINDRADINI RAHVIAN ARIDAMA, FERDY ROYLAND MARPAUNG, YESSY PUSPITASARI

Aim This study analyzed the research trends related to stem cells and secretome in aplastic anemia between 2018 and 2023 using a bibliometric approach to understand developments and research distribution in this field. Methods The Scopus database was used to search for relevant articles on aplastic anemia and its relationship to stem cells or secr...

By CITRA PRIMAVITA MAYANGSARI, HARSONO SALIMO, YULIA LANTI RETNO DEWI, AGUNG PUTRA,, BETTY SURYAWATI, ANNANG GIRI MOELYO

ABSTRACT Aim To examine the association between metabolic parameters and novel cardiometabolic indices with the coronary artery calcium score (CACS). Methods: This retrospective cross-sectional study included 130 patients who underwent coronary computed tomography angiography (CCTA) at the Radiology Clinic of the Clinical Centre of the University...

By ZARINA BABIĆ JUŠIĆ, MIRZA BABIĆ, SABINA PREVLJAK, EMIR BEĆIROVIĆ, FUAD ZUKIĆ, MINELA BEĆIROVIĆ, AMIR BEĆIROVIĆ

  Abstract   Background: Optimal myocardial protection remains challenging in emergency coronary revascularization, especially in patients with severely reduced left ventricular function. Contemporary cardioplegia strategies aim to limit ischemia–reperfusion injury and enhance postoperative ventricular recovery. The aim of this s...

By EMCED KHALIL

Abstract Background: Myocardial infarction (MI) is a cardiovascular disease that is the leading cause of death at all ages. Inflammation and oxidation processes constitute the basic pathophysiology of MI development. C-reactive protein (CRP) and transforming growth factor β (TGF-β) are markers that are often used to evaluate the level of...

By MUHAMMAD SAUGI ABDUH, AHMAD UMAR ALFARUQ, MUH ADYTIA PRASADA, DIMAS NABIH

Aim To describe the clinical picture and laboratory findings, as well as to examine the significance of novel hemogram-derived inflammatory indices in adult patients with measles admitted to a tertiary hospital. Methods This prospective, descriptive, and analytical study included adult patients over 18 years of age with clinical signs of measles, ...

By BERINA HASANEFENDIĆ, AMILA MURATSPAHIĆ, SEMIR HRVO, EMINA HAJROVIĆ HEBIBOVIĆ, LEJLA AVDAGIĆ, ALMEDINA MORO, EMIR ŠEHERČEHAJIĆ, AMIR SANDŽIĆ

Aim Many studies have demonstrated that over half of the World's population is infected with Helicobacter pylori (H. pylori). To evaluate the current H. pylori seroprevalence in Bosnia and Herzegovina (B&H), H. pylori antibodies (immunoglobulin G, IgG) from patients with suspected presence were analyzed. Methods In total, 201/471 (42.7%) males...

By NEJRA BEKTAŠ, LARISA BEŠIĆ, AIDA KULO ĆESIĆ, DAMIR MARJANOVIĆ, JASMINKA PRGUDA-MUJIĆ

Aim Infectious spondylodiscitis is a rare but serious spinal infection that often presents with nonspecific symptoms like fever and back pain, causing delayed diagnosis. This study aimed to describe clinical features, identify etiological agents, and outline treatment approache in patients treated at the Department of Infectious Diseases, Cantonal ...

By ELDIRA HADZIC, MELIHA ŠEHIĆ, RASIM SKOMORAC, NADIRA ZAHIROVIC, MILE BOSILKOVSKI

Aim Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most prevalent adverse event with significant morbidity following ERCP. Several guidelines have suggested the use of rectal diclofenac as a promising option to prevent PEP. Nonetheless, the recommended optimal dose and timing of administration remain unclear. T...

By MAGGIE LIBERTY, TAUFIK SUNGKAR, PEGGY LIBERTY

Aim: The research examined the effects of prolonged oral Lactobacillus rhamnosus intake on rabbit intestinal tissue morphology. Methods: The study included twelve male rabbits aged 10–12 months and weighing 1.5–2.0 kg who received random assignment to two groups of six animals each. The control group received distilled water but the ex...

By TAGHREED AL-FAKJE, FAEHA AL-MASHHADANE, ِASMAA AL-NUAIMY

Aim of this study was to evaluate the correlation between pre-treatment NLR and histopathological differentiation in colorectal cancer, and to assess the diagnostic accuracy of NLR as a predictive biomarker. Methods A retrospective study was conducted at Adam Malik Haji Center General Hospital Medan, North Sumatera. Medical records of 45 colorecta...

By EDWIN SALEH SIREGAR, MUHAMMAD AL ANAS, DEDY HERMANSYAH

Aim: To examine the likelihood of predicting lung cancer survival versus death using Bayesian model based on demographic and laboratory data. Methods: A predictive design using electronic health records from 2012 to 2023 was implemented. IBM SPSS Statistics version 29.0 was used for data descriptive analysis and prediction models were built using ...

By ISLAM BANI MOHAMMAD, MUAYYAD AHMAD

Aim: Breast cancer is the most common cancer found in women including in Indonesia. Breast cancer patients are prone to have anxiety and it affects their quality of life. Interleukin-6 (IL-6) is one of the pro-tumorigenic cytokines that increases in breast cancer and is associated with worse prognosis and cancer metastasis. Several studies demonstr...

By ELLA YUNITA DAULAY, MUSTAFA MAHMUD AMIN, ELMEIDA EFFENDY, VITA CAMELLIA, KAMAL BASRI SIREGAR

Aim To determine the frequency and identify predictors of Continuous positive airway pressure (CPAP) failure in neonates of varying gestational ages in a resource-limited setting, where CPAP is often used beyond the preterm population. Methods prospective observational study of 119 neonates started on CPAP within 24 hours of birth for respiratory ...

By NOOR SAMEER YAHYA, AHMED KHALIL IBRAHIM, AWS AL-NUMAN

Aim Vaccine hesitancy challenges global public health, with parental attitudes significantly impacting childhood immunization. This study examined parental perceptions of vaccine safety, effectiveness, and decision-making factors in Bosnia and Herzegovina. Methods A cross-sectional survey was conducted in March 2025 with 233 parents at a Primary H...

By ANESA TERZIĆ, ELMA MUJAKOVIĆ, EMIR BEĆIROVIĆ, MINELA BEĆIROVIĆ, ALMIRA ĆOSIĆKIĆ

Aim:Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of intermediate biological potential, characterized by spindle cell proliferation and significant inflammatory component. This study aimed to determine the clinicopathologic characteristics, the clinical outcomes of inflammatory myofibroblastic tumor cases in the low-volume...

By ASMIR JONUZI, ILHANA TINJAK, MELIKA BUKVIC, BENJAMIN KULOVAC, NUSRET POPOVIC, EMIR MILISIC, ZLATAN ZVIZDIC

Aim To analyze the effect of vitamin D administration on serum 25(OH)D levels and biomarkers of metabolic syndrome and atherosclerosis (homeostatic model assessment of insulin resistance [HOMA-IR], adiponectin, homocysteine, and high sensitivity C-reactive protein [hs-CRP]) in epilepsy patients receiving enzymatic antiseizure medications (ASMs). M...

By SRI HANDAYANI, ZEN HAFY, FITRI OCTAVIANA, ZULKHAIR ALI, NITA PARISA, ASTRI BUDIKAYANTI, DESSY AGUSTINI, RADIYATI UMI PARTAN

Aim: To assess the impact of cognitive impairments on various domains of quality of life in patients with multiple sclerosis (MS). Methods: This prospective study included 135 MS patients and 50 healthy controls. Participants were divided into three groups: patients with MS for more than one year (n=85), newly diagnosed MS patients (n=50), and h...

By AIDA ŠEHANOVIĆ, SULJO KUNIĆ, ANIDA ŠEHANOVIĆ, DŽEVDET SMAJLOVIĆ, EMIR TUPKOVIĆ, OMER Ć. IBRAHIMAGIĆ

Introduction. Ruptured abdominal aortic aneurysm (RAAA) is a life-threatening emergency with high mortality. While conventional risk factors are well recognized, emerging evidence suggests environmental temperature may also influence rupture risk. This relationship has not been studied in Bosnia and Herzegovina. The aim of this study is to inv...

By MUHAMED DJEDOVIĆ, ARMIN SLJIVO, BEDRUDIN BANJANOVIC1, HARIS VUKAS, EDIN KABIL, ALDEN BEGIC, SAMED DJEDOVIĆ

OBJECTIVE: To determine changes in inflammatory parameter values ​​after foam sclerotherapy of varicose vein. The values ​​of inflammatory parameters were taken and compared immediately after treatment and seven days after treatment. METHODS: A total of 41 patients with verified varicose vein disease were included in this study. They were monitore...

By ANEL OKIC, MAGRIN ALIC, HASIB MUJIC, AMEL HADZIMEHMEDAGIC, NERMINA BABIC, NESINA AVDAGIC

Aim: To investigate the impact of three-dimensional (3D) printing technology on vascular surgery, focusing on its role in preoperative planning and surgical training. Methods: A systematic review was conducted of studies published between 2017 and 2024 that evaluated 3D printing in vascular surgery. Databases searched included MEDLINE an...

By HARIS VUKAS, SAMRA KADIĆ-VUKAS, SUMEJA ĆATIĆ, RUVEJDA DIZDAREVIĆ, FARAH DEDOVIĆ, NAIL ŠEHIĆ, MERIM JUSUFBEGOVIĆ

Objective: For evaluation of predictive factors of sponataneous conception after saline infused sonosalpingography (SIS). Method: A prospective study was conducted from August 2023 to December 2024 at reproductive medial unit  at Mosul/Iraq.  100 women were recruited and categorized in to  two groups: pregnant after SIS   ...

By DALAL RAMADHAN, MARWA AL-RASHEEDY, LUMA ALSARRAJ

Aim Teriparatide, a synthetic analog of the active fragment of human parathyroid hormone (PTH 1–34), is a clinically approved anabolic treatment for osteoporosis. While its bone-forming capacity is well-documented, evidence regarding its systemic safety, particularly in relation to male reproductive health, remains limited. Aim: This study w...

By OMAR AMEEN, GHADA TAQA

Aim Mild traumatic brain injury (mTBI) presents diagnostic challenges, with head computed tomography (head CT) often overutilized in emergency settings. Blood biomarkers such as glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) have shown promise in early injury detection. Aim of this study was to evaluate ...

By ALMA OSMIĆ-HUSNI, RADIVOJ JADRIĆ, SVETLANA JOVIĆ- LACKOVIĆ, AIDA ŽABIĆ, SABINA ČAMDŽIĆ-SMAJIĆ

Aim To compare outcomes and minimal clinically important differences (MCID) between single-level laminectomy (SLL) and two-level laminectomy (TLL) for lumbar spinal stenosis (LSS). Methods This prospective study included 119 patients with confirmed LSS who underwent SLL or TLL at Cantonal Hospital Zenica from January 2018 to January 2025. Assessme...

By EMIR BEGAGIĆ, HAKIJA BEČULIĆ, FAHRUDIN ALIĆ, ANES MAŠOVIĆ, GORAN LAKIČEVIĆ, LEMANA BULJUBAŠIĆ, MUHAMED HARAČIĆ

Aim Osteoporosis is a global health concern, characterized by reduced bone density, microarchitectural changes, and an increased risk of fractures. The prevalence of osteoporosis is rising, particularly in developing countries. In Indonesia, the incidence of upper femur fractures due to osteoporosis is notably high. As human studies are limited, an...

By PANJI SANANTA, RESPATI SURYANTO DRADJAT, ISTAN IRMANSYAH IRSAN, ANDHIKA YUDISTIRA, ADITYA ROSID DWI ANWAR

Aim Recent studies challenge the initial belief that medial unicompartmental knee arthroplasty (UKA) is contraindicated for patients with anterior cruciate ligament deficiency (ACLD) due to increased risk of periprosthetic tibial fractures, revealing promising outcomes with advancements in surgical techniques and patient selection. This study aimed...

By KRISNA YUARNO PHATAMA, EDI MUSTAMSIR, ANANTO SATYA PRADANA, DOMY PRADANA PUTRA, YUDHA ANANTHA KHAERUL PUTRA, FELIX GIOVANNI HARTONO

Background Distal radius fractures are among the most common orthopedic injuries, posing significant challenges due to their high prevalence and potential for long-term functional impairment. Volar locking plates have emerged as the gold standard for managing unstable and extra-articular fractures, offering superior outcomes compared to traditiona...

By GIUSEPPE ROVERE, FRANCESCO BOSCO, GIULIO VIGNI, ENNIO SINNO, ANDREA PERNA, FORTUNATO GIUSTRA, FRANCESCO LIUZZA, AMARILDO SMAKAJ, FERNANDO DE MAIO, ANTONIO ZIRANU, GIUSEPPE TULUMELLO, LAWRENCE CAMARDA

Aim To demonstrate the possibilities of reconstructing a prosthetic stump in a complex defect using staged osteotomy and lengthening, since for successful prosthetic replacement of the tibial stump, its sufficient length is necessary, which is not always possible. Methods In this article, we present a 25-year-old man diagnosed with a non-prostheti...

By YURII OLEKSIIOVYCH BEZSMERTNYI, VIKTOR IVANOVYCH SHEVCHUK, OLEXANDER YURIYOVYCH BRANITSKY, OLEXANDER YURIYOVYCH BEZSMERTNYI, DMYTRO VADYMOVYCH BONDARENKO

Aim Metacarpal fractures are common hand injuries, frequently treated with closed reduction and internal fixation (CRIF) using Kirschner wires (K-wires). While exposed K-wires allow for simple hardware removal and early mobilization, their use is traditionally associated with a higher risk of pin tract infections. There is a lack of studies f...

By ANDREA CRUCIANI, SILVIA PIETRAMALA, ALESSIO GRECO, ALESSANDRO EL MOTASSIME, CAMILLO FULCHIGNONI, LORENZO ROCCHI

Aim Unintended scaphoid excision is a rare but serious complication that can occur during surgical procedures involving the trapezium, including but not limited to trapeziectomy. Although prosthetic replacement is increasingly favored in the treatment of rhizarthrosis, trapeziectomy (with or without ligamentoplasty) remains a widely used and effect...

By CAMILLO FULCHIGNONI, SILVIA PIETRAMALA, CHIARA MUCI, ALESSANDRO EL MOTASSIME, ANDREA CRUCIANI, LORENZO ROCCHI, GIANFRANCO MERENDI

Aim Tendon healing involves a crucial proliferative phase, during which fibroblasts and fibrocytes orchestrate collagen deposition. The use of liquid nitrogen (LN) in orthopedic oncology may inadvertently affect adjacent tendon tissues. This study aimed to evaluate the impact of LN exposure on the histological features of tendon healing. Methods T...

By ISTAN IRMANSYAH IRSAN, EDI MUSTAMSIR, PANJI SANANTA, SATRIA PANDU PERSADA ISMA, DANDY DRESTANTO ADIWIGNYO, HUDZAIFAH AL AZMI MANAF, ADYTIA ANDREYTA REFA

Aim Orthopedic implants must meet specific criteria, including mechanical strength, durability, and biocompatibility. This study compares the immune response of zirconia, polyether ether ketone (PEEK), and stainless-steel implants in vivo, focusing on lymphocyte and fibroblast infiltration as indicators of immune activation. Methods A total of 27 ...

By AGUNG RIYANTO BUDI SANTOSO, RESPATI SURYANTO DRADJAT, EDI MUSTAMSIR, SETYAWAN PURNOMO SAKTI, PANJI SANANTA, HIDAYAT SUJUTI, HERI SUROTO

Introduction: Environmental factors may influence postoperative outcomes and quality of life following total hip replacement (THR). This study investigated the impact of the geographical location of the surgical site, as well as the patient’s place of birth and residence, on treatment outcomes in individuals with artificial hips. Methods: A ...

By SLAVKO MANOJLOVIC, DRAGANA DRAGICEVIC-CVJETKOVIC, NEMANJA MANOJLOVIĆ, ZELJKO JOVIČIĆ, MIRKO MANOJLOVIĆ, FERID KRUPIĆ

Aim To assess the level of knowledge about risk factors and prevention of lung cancer among medical students, and to identify differences in knowledge based on the year of study and previous secondary education background. Methods The study was conducted among 223 students of the School of Medicine, University of Zenica, and the School of Medicine...

By AMAR TERZIMEHIĆ, ELMA KUDUZOVIĆ, NINO HASANICA, MUHAMED SKOMORAC, ERNA TERZIĆ, IMAN KOVAČ